Institute of Longevity: A Unique Concept
An integrated and innovative approach to transforming aging through Science: Research, Innovation, and Personalized Care to:
Live younger, longer...!
• The IRLB supports the unique Institute of Longevity project, initiated by Dr. Jean-Marc Lemaitre.
• In response to the demographic challenges of aging and the urgent need to accelerate the translation of scientific discoveries into therapeutic solutions, the Institute of Longevity offers a unique, integrated approach that combines scientific excellence, technological innovations, and personalized medicine to revolutionize human health and longevity.
• Its objectives include a better understanding of aging mechanisms, the development of cutting-edge clinical solutions, and access to personalized diagnostics and treatments, leveraging artificial intelligence and in-depth biomarker analysis.
• Located in a prestigious setting near Montpellier, the Institute of Longevity positions itself as a key player in tackling health and longevity challenges, both today and for future generations.
At the Forefront of Longevity Science
• The Institute for Healthy Longevity is an ambitious and unique initiative in France, dedicated to transforming our vision of aging. By integrating advanced research, innovative technologies, and clinical care, the Institute aims to address the challenges and opportunities of an extended lifespan.
• Located in the Montpellier Metropolis, a unique hub of scientific and medical innovation, the Institute will bring together researchers, engineers, physicians, longevity and health experts, startups, and research institutions to develop solutions for extending healthy lifespan. Its mission is to translate scientific discoveries into tangible results, enabling people to live longer and healthier lives.
The Institute’s Objectives Are Based On:
• Cutting-edge research: Exploring the fundamental causes of aging and developing strategies to counteract them.
• Public-private collaborations: Establishing partnerships between academic teams, startups, and global organizations to drive innovation.
• Personalized clinical care: Providing diagnostics, prevention programs, and tailored treatments to enhance healthy lifespan, supported by specialized clinicians.
Leadership & Vision
Dr. Jean-Marc Lemaitre: A pioneer in regenerative medicine and longevity science, embodying a bold vision to transform aging.
Research Director at INSERM, Co-Director of the Institute of Regenerative Medicine and Biotherapies in Montpellier since 2015, he is a pioneer in cellular aging research and regenerative medicine. Since 2006, his team has made groundbreaking advances in cellular reprogramming and age reversal. His work has redefined our understanding of aging mechanisms and opened new avenues to treat aging and prevent age-related diseases.
With more than 70 scientific publications in prestigious journals and two key books: "Guérir la vieillesse" (Curing Old Age) in 2022, published by Humensciences Editions and "Décider de son âge" (Choosing Your Age) in 2024, published by Allary Editions. He embodies excellence and innovation. Today, he leads a unique project in France: the Institute of Longevity, which combines research, startups, and clinical applications to revolutionize how we approach aging.
Under his leadership, a dedicated INSERM research unit has been proposed, focusing exclusively on the biology of aging and healthy longevity. This unit will concentrate its efforts around three pillars: EVALUATE, PREVENT, TREAT aging
Why Now? The Challenges of Aging
THE NEED TO ACT: AGING AS A GLOBAL PRIORITY
The world’s population is aging at an unprecedented rate. By 2050, more than 2.1 billion people will be 60 years and older, creating opportunities but also challenges for societies worldwide.
Key Challenges:
• Health Disparities: While some enjoy long years of good health, others face inequalities in access to care and support systems, leading to gaps in healthy life expectancy.
• Age-related Diseases: Neurodegenerative diseases, cardiovascular conditions, osteoporosis, and osteoarthritis are on the rise, placing an increasing burden on healthcare systems.
• Scientific Translation: While knowledge about aging is advancing, there is still a gap between discoveries and their real-world application on a global scale—one that must be bridged. The Institute of Longevity aims to fill this gap.
By treating aging as the fundamental cause of age-related diseases, the Institute seeks to delay or even prevent the onset of chronic conditions and enhance overall health.
Research at the Heart of the Institute
TRANSFORMING AGING SCIENCE INTO HEALTH SOLUTIONS
The Institute of Longevity will focus on understanding the biological mechanisms of aging and translating this knowledge into innovative therapies and diagnostic tools. Research will cover multiple fields, aiming to slow aging, improve healthy lifespan, and reduce age-related diseases.
Decoding the Mechanisms of Healthy Aging:
• Analyzing exceptional longevity in human cohorts, such as centenarians and supercentenarians, to identify genetic, epigenetic, and environmental factors contributing to resilience and prolonged health, using AI-based analysis.
• Using various cellular models to recreate aging processes in vitro, particularly those derived from iPSCs, providing a platform to study cellular senescence, disease progression, and rejuvenation strategies.
• Studying pathological conditions of premature aging (e.g., progeria) to understand accelerated aging processes and identify therapeutic opportunities.
• Leveraging the resilience traits of extraordinary species like planarians and tardigrades, among others, to discover new mechanisms of regeneration and longevity.
Exploring the Hallmarks of Aging:
• Cellular aging markers provide an opportunity to better understand biological aging mechanisms, evaluate their progression, and develop new therapeutic targets.
• The Institute will develop innovative therapies, including senolytics to eliminate senescent cells, and cellular reprogramming-based therapies to rejuvenate tissues.
• These approaches will guide the development of targeted strategies to slow aging and improve overall health.
Developing Diagnostics & Regenerative Therapies:
• Designing innovative diagnostic tools to assess biological age and detect early markers of age-related diseases, integrating multi-omics approaches (genomics, proteomics, metabolomics, epigenomics).
• Utilizing AI and bioinformatics to refine aging biomarkers and develop personalized health strategies.
• Creating regenerative therapies to restore the physiological functions of aging tissues and organs, integrating lifestyle-based interventions (nutrition, physical activity, environment, sleep).
Personalized Clinical Care
REVOLUTIONIZING LONGEVITY MEDICINE
The Longevity Clinic within the Institute will be a central pillar of its mission, offering personalized care based on the latest aging and longevity research.
Key Features:
• Assessment of Biological Age & Health Status: Advanced diagnostics based on multi-omics technologies (genomics, proteomics, metabolomics) and AI-driven analysis.
• Tailored Prevention Programs: Personalized plans integrating nutrition, physical activity, stress management, and sleep optimization.
• Access to Cutting-Edge Research Innovations: Interventions based on the latest advancements in regenerative medicine, as well as new molecules and innovations currently in clinical trials that will be accessible.
• Monitoring Aging Progression: Continuous adjustments to care plans, ensuring maximum effectiveness for healthy longevity.
A Unique Location in the South of France
Located in the Montpellier Metropolis, the Institute will benefit from a strategic position to become a global leader in longevity science.
Key Advantages of This Location:
• Proximity to Excellence: Close collaborations with academic institutions, research centers, startups, and the Montpellier University Hospital (CHU).
• Connection to MedValley: Integrated into a thriving biomedical innovation ecosystem.
• Inspiring Environment: A unique blend of historical heritage and modern infrastructure.
• Global Vision: Attracting international talent and fostering worldwide collaborations.
The Institute will merge tradition and modernity, leveraging Montpellier’s strengths and dynamism to provide groundbreaking solutions for healthy aging.
